Strategic distribution network planning with smart grid technologies

This paper presents a multiyear distribution network planning optimization model for managing the operation and capacity of distribution systems with significant penetration of distributed generation (DG). The model considers investment in both traditional network and smart grid technologies, including dynamic line rating, quadrature-booster, and active network management, while optimizing the settings of network control devices and, if necessary, the curtailment of DG output taking into account its network access arrangement (firm or non-firm). A set of studies on a 33 kV real distribution network in the U.K. has been carried out to test the model. The main objective of the studies is to evaluate and compare the performance of different investment approaches, i.e., incremental and strategic investment. The studies also demonstrate the ability of the model to determine the optimal DG connection points to reduce the overall system cost. The results of the studies are discussed in this paper

The Association Between Obstructive Sleep Apnea and Depression in Older Adults

Background: Depression is the most frequent psychiatric disorder among the elderly. Obstructive sleep apnea (OSA) is a chronic and prevalent disease that has an ambiguous role in triggering depression. Several researches with contradictory findings have been performed about the association between OSA and depression. Objectives: This study aimed to investigate the association between OSA and depression among elderly. Patients and Methods: A total of 350 home residing elderly took part in this case-control study. The participants were selected using clustering method. All cases were divided into two groups of depressed and non-depressed using the geriatric depression scale (GDS). Then they were matched in age, gender, education and body mass index (BMI). Berlin questionnaire (BQ) was used to diagnose OSA. Data analysis was performed using Mann-Whitney U test, t-test, Chi-square and Fisher’s exact tests and odds ratio. Results: Totally, 60.6 % of depressed group and 18.9 % of non-depressed group were in high risk for OSA. A significant association was found between OSA and depression (P < 0.001, OR = 6.61, CI 95 % = 4.1 - 10.7). In addition, a significant association was found between gender and OSA (P = 0.008). Conclusions: OSA was associated with depression among the elderly patients. Given the high prevalence of OSA in older adults, implementation of screening methods is necessary to identify people at high risk of OSA

\u3ci\u3eDrosophila\u3c/i\u3e SNAP-29 Is an Essential SNARE That Binds Multiple Proteins Involved in Membrane Traffic

Each membrane fusion event along the secretory and endocytic pathways requires a specific set of SNAREs to assemble into a 4-helical coiled-coil, the so-called trans-SNARE complex. Although most SNAREs contribute one helix to the trans-SNARE complex, members of the SNAP-25 family contribute two helixes. We report the characterization of the Drosophila homologue of SNAP-29 (dSNAP-29), which is expressed throughout development. Unlike the other SNAP-25 like proteins in fruit fly (i.e., dSNAP-25 and dSNAP-24), which form SDS-resistant SNARE complexes with their cognate SNAREs, dSNAP-29 does not participate in any SDS-resistant complexes, despite its interaction with dsyntaxin1 and dsyntaxin 16 in vitro. Immunofluorescence studies indicated that dSNAP-29 is distributed in various tissues, locating in small intracellular puncta and on the plasma membrane, where it associates with EH domain-containing proteins implicated in the endocytic pathway. Overexpression and RNAi studies suggested that dSNAP-29 mediates an essential process in Drosophila development

Prognostic factors for esophageal squamous cell Carcinoma-A Population-Based study in Golestan province, Iran, a high incidence area

Golestan Province in northern Iran is an area with a high incidence of esophageal squamous cell carcinoma (ESCC). We aimed to investigate prognostic factors for ESCC and survival of cases in Golestan, on which little data were available. We followed-up 426 ESCC cases participating in a population-based case-control study. Data were analyzed using the Kaplan-Meier method and the Cox proportional hazard models. Median survival was 7 months. Age at diagnosis was inversely associated with survival, but the association was disappeared with adjustment for treatment. Residing in urban areas (hazard ratio, HR = 0.70; 95 CI 0.54-0.90) and being of non-Turkmen ethnic groups (HR = 0.76; 95 CI 0.61-0.96) were associated with better prognosis. In contrast to other types of tobacco use, nass (a smokeless tobacco product) chewing was associated with a slightly poorer prognosis even in models adjusted for other factors including stage of disease and treatment (HR = 1.38; 95 CI 0.99-1.92). Opium use was associated with poorer prognosis in crude analyses but not in adjusted models. Almost all of potentially curative treatments were associated with longer survival. Prognosis of ESCC in Golestan is very poor. Easier access to treatment facilities may improve the prognosis of ESCC in Golestan. The observed association between nass chewing and poorer prognosis needs further investigations; this association may suggest a possible role for ingestion of nass constituents in prognosis of ESCC. © 2011 Aghcheli et al

A New Generalized Varentropy and its Properties

The variance of Shannon information related to the random variable X, which is called varentropy, is a measurement that indicates, how the information content of X is scattered around its entropy and explains its various applications in information theory, computer sciences, and statistics. In this paper, we introduce a new generalized varentropy based on the Tsallis entropy and also obtain some results and bounds for it. We compare the varentropy with the Tsallis varentropy. Moreover, we explain the Tsallis varentropy of the order statistics and analyse this concept in residual (past) lifetime distributions and then introduce two new classes of distributions by them.The authors would like to thank the editor and anonymous referees for their valuable comments and suggestions that improved the quality of the paper

Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

GATA-3 is essential for T cell development from the earliest stages. However, abundant GATA-3 can drive T lineage precursors to a non–T cell fate, depending on Notch signaling and developmental stage. Here, overexpression of GATA-3 blocked the survival of pro–T cells when Notch-Delta signals were present but enhanced viability in their absence. In fetal thymocytes at the double-negative 1 (DN1) stage and DN2 stage but not those at the DN3 stage, overexpression of GATA-3 rapidly induced respecification to the mast cell lineage with high frequency by direct transcriptional 'reprogramming'. Normal DN2 thymocytes also showed mast cell potential when interleukin 3 and stem cell factor were added in the absence of Notch signaling. Our results suggest a close relationship between the pro–T cell and mast cell programs and a previously unknown function for Notch in T lineage fidelity

Antioxidant activity, phenolics content and total flavonoids of caper fruit (Caparis spinosa) at different maturity stages

Background and objectives: Capparis spinosa is a perennial herb belonging to the Capparidaceae family that is mainly distributed in arid and semi-arid regions of the tropical and subtropical world. The plant is a potential source of valuable nutrients that is valued for human food. The fruit of this plant, being a rich source of high-value components, is usually pickled and added to salads, sauces and jams. Different organs have different amounts of biochemical compounds. Maturity stages have important effects on fruit quality. In order to determine the best time for obtaining the maximum secondary metabolites (phenolics content, antioxidant activity and total flavonoids) from caper fruits, three stages of maturity (unripe, ripe and over ripe fruits) were studied. Methods: Measured factors were antioxidant activity (DPPH radical scavenging property) total flavonoids, flavones and flavonols content, total phenolic compounds (Folin reagent by calorimetric method), tannin content and carbohydrate content. Results: The results showed the significant effect of fruit maturity on most measured traits. Maturity decreased flavones and flavonoles (0.72, 0.34 and 0.22 mg quercetin/g respectively) and total flavonoids content (7.20, 3.61 and 3.51 mg quercetin/g respectively) while total phenolic and carbohydrate has increased during ripening. Antioxidant activity had not significant changed during ripening. Conclusion: Unripe fruits were the best samples for achieving the maximum flavonoids content that were assumed as major compound of Caper fruit

Comparative study of essential oil content and composition of Ducrosia anethifolia at two phenologocal stage

Background and objectives: Ducrosia anethifolia is one species which belongs to Apiaceae family that is used to improve the odor of foods and drinks. It is used also to treat catarrh, headache and backache in folk medicine. The herb is also reported to relax the mind and body and induce a peaceful sleep. The growing stage has an important role in quantity and quality of medicinal plants metabolite. In this study, the oil content and composition of D. anethifolia at two growth stages (full flowering and seed formation) were studied. Methods: Oil content of this plant was isolated by hydrodistillation method by Clevenger type apparatus. Chemical composition was detected by GC and GC/MS analysis. Results: The results showed that the phenological stage had significant effect on the oil content and composition. Oil content at seed formation was more than the flowering stage (0.24 and 0.96% v/w, respectively). At the flowering stage, n-dodecanal (14.43%), dodecanal (13.30%) and n-decanoic acid (11.61%) were the major constituents while in the seed formation stage, they were detected slightly. Besides, at seed formation stage cis-chrysanthenyl acetae (39.06%), cubenol (7.97%) and p-cymene-7-ol (4.30%) were identified as the main composition. Conclusion: The results showed depending on our goal for each plant usage, the harvest time could be different; during seed formation the oil content increased significantly